LC-MS/MS method development and validation for quantitative analyses of 2-aminothiazoline-4-carboxylic acid - a new cyanide exposure marker in post mortem blood

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LC-MS/MS method development and validation for quantitative analyses of 2-aminothiazoline-4-carboxylic acid - a new cyanide exposure marker in post mortem blood

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作者：Joanna Giebułtowicz^a ; ^{joanna.giebultowicz@wum.edu.pl" class="auth_mail" title="E-mail the corresponding author} ; Monika Rużycka^a ; Marcin Fudalej^b ; Paweł Krajewski^b ; Piotr Wroczyński^a
关键词：ATCA ; 2-aminothiazoline-4-carboxylic acid ; ATCA-13C ; 15N2 ; 2-aminothiazoline-4-carboxylic acid-13C ; 15N2 ; ATZA ; 2-aminothiazole-4-carboxylic acid ; DNS ; 5-(dimethylamino)naphthalene-1-sulfonyl chloride ; EMA ; European Medicines Agency ; ESI ; electrospray ionization ; ESI/MS/MS ; electrospray ionization tandem mass spectrometry ; FDA ; US Food and Drug Administration ; HILIC ; hydrophilic interaction liquid chromatography ; IS ; internal standard ; LC-MS/MS ; liquid chromatography coupled to tandem mass spectro
刊名：Talanta
出版年：2016
出版时间：1 April 2016
年：2016
卷：150
期：Complete
页码：586-592
全文大小：455 K

文摘

•: The first time method development of ATCA extraction from post mortem blood.
•: All validation experiments met the acceptance criteria of FDA and EMA.
•: ATCA concentrations in post mortem human blood have been established for the first time.