Variability in the effect of antidepressants upon Wfs1-deficient mice is dependent on the drugs’ mechanism of actions

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Variability in the effect of antidepressants upon Wfs1-deficient mice is dependent on the drugs’ mechanism of actions

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作者：Riin Reimets^a ; ¹ ; ^{riin.reimets@ut.ee" class="auth_mail" title="E-mail the corresponding author} ; Sirli Raud^a ; ¹ ; Maarja Loomets^a ; Tanel Visnapuu^a ; Vallo Volke^a ; ^b ; Ain Reimets^a ; Mario Plaas^a ; Eero Vasar^a
关键词：AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ; DA ; dopamine ; 5-HIAA ; 5-hydroxyindoleacetic acid ; 5-HT ; serotonin ; HVA ; homovanillic acid ; NA ; noradrenaline ; NMDA ; N-methyl-d-aspartate ; SERT ; serotonin transporter ; SSRI ; selective serotonin reuptake inhibitor ; TST ; tail suspension test ; WFS1 ; Wolfram Syndrome 1 gene ; WS ; Wolfram syndrome
刊名：Behavioural Brain Research
出版年：2016
出版时间：15 July 2016
年：2016
卷：308
期：Complete
页码：53-63
全文大小：2646 K

文摘

•: Ketamine, escitalopram and amitripyline had a stronger antidepressant effect upon homozygous mice.
•: Amitriptyline and desipramine potentiated glucose elevation in homozygous mice.
•: Escitalopram and bupropion did not affect the glucose concentration of homozygous mice.
•: Ketamine improved the impaired glucose metabolism of homozygous mice.

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