Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes

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Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes

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作者：Harinath Doodhi¹ ; ⁶ ; ⁷ ; Andrea E. Prota² ; ⁶ ; Ruddi Rodrí ; guez-Garcí ; a¹ ; ⁶ ; Hui Xiao³ ; Daniel W. Custar⁴ ; Katja Bargsten² ; ⁸ ; Eugene A. Katrukha¹ ; Manuel Hilbert² ; ⁹ ; Shasha Hua¹ ; Kai Jiang¹ ; Ilya Grigoriev¹ ; Chia-Ping H. Yang³ ; David Cox⁵ ; ¹⁰ ; Susan Band Horwitz³ ; Lukas C. Kapitein¹ ; ^{l.kapitein@uu.nl" class="auth_mail" title="E-mail the corresponding author} ; Anna Akhmanova¹ ; ^{a.akhmanova@uu.nl" class="auth_mail" title="E-mail the corresponding author} ; Michel O. Steinmetz² ; ^{michel.steinmetz@psi.ch" class="auth_mail" title="E-mail the corresponding author}
刊名：Current Biology
出版年：2016
出版时间：11 July 2016
年：2016
卷：26
期：13
页码：1713-1721
全文大小：2551 K

文摘

•: Eribulin binds to a site on β-tubulin, which is exposed at microtubule plus ends
•: Single Eribulin molecules induce erratic microtubule plus-end growth and catastrophes
•: Eribulin induces EB3 comet splitting
•: Eribulin amplifies a natural pathway of catastrophe induction

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