Oxidative stress in peripheral blood mononuclear cells from patients with Parkinson's disease: Negative correlation with levodopa dosage

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• 作者：Alessandro Prigione ; Barbara Begni ; Alessio Galbussera ; Simone Beretta ; Laura Brighina ; Rosanna Garofalo ; Simona Andreoni ; Roberto Piolti and Carlo Ferrarese
• 关键词：Parkinson's disease ; Levodopa ; Oxidative stress ; PBMC ; Reactive oxygen species ; Glutathione reductase
• 刊名：Neurobiology of Disease
• 出版年：2006
• 出版时间：July 2006
• 年：2006
• 卷：23
• 期：1
• 页码：36-43
• 全文大小：358 K

文摘

Oxidative stress, resulting from the imbalance between reactive oxygen species (ROS) formation and antioxidant defenses, plays a major role in the pathogenesis of Parkinson's disease (PD). However, the contribution of levodopa (LD) therapy to oxidative damage is still debated. We investigated oxidative stress in peripheral blood mononuclear cells (PBMCs) from LD-treated PD patients and healthy subjects. Increased ROS production associated with unaltered glutathione reductase activity was detected in PBMC from PD patients. LD daily dosage appeared to be inversely correlated with ROS levels and positively associated with GR activity, suggesting a protective role for LD on PBMCs redox status. Our data support the view of systemic oxidative stress involvement in PD and give further rationale for using PBMCs as an easily accessible ex-vivo dopaminergic model for exploring the biological effects of LD therapy.