Ferromagnetic particles as a rapid and robust sample preparation for the absolute quantification of seven eicosanoids in human plasma by UHPLC-MS/MS

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Ferromagnetic particles as a rapid and robust sample preparation for the absolute quantification of seven eicosanoids in human plasma by UHPLC-MS/MS

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作者：Anna Catharina Suhr ; ¹ ; ^{anna.suhr@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author} ; Mathias Bruegel¹ ; Barbara Maier ; Lesca Miriam Holdt ; Alisa Kleinhempel ; Daniel Teupser ; Stefanie H. Grimm ; Michael Vogeser
关键词：Magnetic particles ; Eicosanoids ; Sample preparation ; Liquid chromatography ; Mass spectrometry ; Validation
刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
出版年：2016
出版时间：1 June 2016
年：2016
卷：1022
期：Complete
页码：173-182
全文大小：1574 K

文摘

•: Use of ferromagnetic particles as novel deproteination technique.
•: Combination of magnetic particles with on-line SPE for high through-put capability.
•: UHPLC–MS/MS method for absolute quantification of seven eicosanoids.
•: Validation based on EMA guideline.
•: Generic approach improving automation in LC–MS/MS.

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