Annexin A2 can be recognized by antibodies in sera from patients with obstetric complications in early or later stages of pregnancy.

The prevalence of anti-annexin A2 antibodies was higher compared as that of anti-annexin A5 antibodies.

Anti-annexin A2 antibodies were detected independently of antiphospholipid and anti-annexin A5 antibodies.

Further studies are needed to determine whether annexin A2 is critical for maintenance of placental integrity.