Exposure to benzo[a]pyrene impairs decidualization and decidual angiogenesis in mice during early pregnancy

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• 作者：Xueyan Li¹ ; ^{821820877@qq.com} ; Cha Shen¹ ; ^{shencha@yeah.net} ; Xueqing Liu ^{a68733172@online.cq.cn} ; Junlin He ^{hejunlin_11@aliyun.com} ; Yubin Ding ^{dingyb@gmail.com} ; Rufei Gao ^{gao_ru_fei@163.com} ; Xinyi Mu ^{Anniemachine@163.com} ; Yanqing Geng ^{aqing000@163.com} ; Yingxiong Wang ^{wyx61221@aliyun.com} ; Xuemei Chen ; ^{shirly-cxm@163.com}
• 关键词：Benzo[a]pyrene ; Decidualization ; Decidual angiogenesis
• 刊名：Environmental Pollution
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：222
• 期：Complete
• 页码：523-531
• 全文大小：3220 K
• 卷排序：222

文摘

BaP impaired decidualization response during early pregnancy. Expression of decidualization-related factors were altered after BaP treatment. BaP inhibited decidual angiogenesis during early pregnancy. The P4–PR-regulated VEGF-A–VEGFR2 signaling pathway plays a key role in this process.