The deubiquitinating enzyme activity of USP22 is necessary for regulating HeLa cell growth

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The deubiquitinating enzyme activity of USP22 is necessary for regulating HeLa cell growth

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作者：Ying-Li Liu^a ; Jie Zheng^b ; Li-Juan Tang^a ; Wei Han^a ; Jian-Min Wang^a ; Dian-Wu Liu^a ; Qing-Bao Tian^a ; ^{tianqingbao1980@aliyun.com" class="auth_mail" title="E-mail the corresponding author}
关键词：USP ; ubiquitin-specific protease ; DUBs ; deubiquitinating enzymes ; USP22 ; ubiquitin-specific protease 22 ; qRT-PCR ; quantitative real-time polymerase chain reaction
刊名：Gene
出版年：2015
出版时间：1 November 2015
年：2015
卷：572
期：1
页码：49-56
全文大小：1083 K

文摘

•: USP22 down-regulation can affect cell cycle but not apoptosis.
•: USP22 promotes cell proliferation via the c-Myc/cyclin D2, BMI-1 and p53 pathways.
•: The deubiquitin enzyme activity is necessary for the regulatory effect.

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