Functional inorganic films fabricated by PIII(-D) for surface modification of blood contacting biomaterials: Fabrication parameters, characteristics and antithrombotic properties

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• 作者：Ping Yang ; Nan Huang ; Yongxiang Leng ; Guojiang Wan ; Ansha Zhao ; Junying Chen ; Jin Wang ; Hong Sun
• 关键词：Biomaterials ; Functional inorganic film ; PIII-D
• 刊名：Surface and Coatings Technology
• 出版年：2007
• 出版时间：23 April 2007
• 年：2007
• 卷：201
• 期：15
• 页码：6828-6832
• 全文大小：1051 K

文摘

One of the important considerations of antithrombotic biomaterial improvement is to control the response of blood cells and plasma proteins to the materials. Material surface characteristics can be suggested as the important factors that influence the response of blood to materials. Thus, modifying the surface characteristics of a material becomes an important way to endue it with the antithrombotic function of preventing blood cell/plasma protein activation. This article is going to summarize results from previous studies on functional inorganic films coated with blood contacting biomaterials, including fabricating condition, characteristics and antithrombotic function. The functional inorganic films of Ti–O, a-C:N:H and Si–N synthesized using PIII-D on the surface of a biomaterial can endue it with the antithrombotic function of preventing platelet adhesion/activation. The characteristics of the films changed with alteration of the fabrication condition and influenced their antithrombotic function strongly. The in vitro test results showed that improved biomaterial surfaces with special antithrombotic function can be obtained from the optimization of the fabrication condition according to the understanding of the blood–materials interaction.