Synthesis and structure elucidation of new μ-oxamido-bridged dicopper(II) complex with in vitro anticancer activity: A combined study from experiment verification and docking calculation on DNA/protein-binding property

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Synthesis and structure elucidation of new μ-oxamido-bridged dicopper(II) complex with in vitro anticancer activity: A combined study from experiment verification and docking calculation on DNA/protein-binding property

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作者：Ling Zhu^a ; Kang Zheng^a ; Yan-Tuan Li^a ; ^{yantuanli@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Zhi-Yong Wu^a ; Cui-Wei Yan^b ; ^{cuiweiyan@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Dicopper(II) complex ; Crystal structure ; Molecular docking ; DNA/BSA binding ; Anticancer activity ; N ; N&prime ; -bis(substituted)oxamide
刊名：Journal of Photochemistry and Photobiology B: Biology
出版年：2016
出版时间：February 2016
年：2016
卷：155
期：Complete
页码：86-97
全文大小：1584 K

文摘

•: A new dicopper(II) complex is characterized by X-ray analysis and other methods.
•: The synthesized complex is active against the selected tumor cell lines.
•: The DNA/BSA-binding are studied theoretically and experimentally.
•: The effects of terminal ligand and chelate ring arrangement are discussed.