Role of HLA-G 14bp deletion/insertion and +3142C>G polymorphisms in the production of sHLA-G molecules in relapsing-remitting multiple sclerosis

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• 作者：Roberta Rizzo ; Daria Bortolotti ; Nadia Ben Fredj ; Antonella Rotola ; Francesca Cura ; Massimiliano Castellazzi ; Carmine Tamborino ; Silva Seraceni ; Eleonora Baldi ; Loredana Melchiorri ; Maria Rosaria Tola ; Enrico Granieri ; Olavio R. Baricordi ; Enrico Fainardi
• 刊名：Human Immunology
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：73
• 期：11
• 页码：1140-1146
• 全文大小：517 K

文摘

HLA-G is believed to act as an anti-inflammatory molecule in Multiple Sclerosis (MS). The 3¡ä untranslated region of the HLA-G gene is characterized by two polymorphisms, DEL/INS14bp and +3142C>G, which control soluble HLA-G (sHLA-G) production. The influence of these two HLA-G variants on sHLA-G serum and cerebrospinal fluid (CSF) levels was investigated in 69 Relapsing-Remitting MS patients grouped in magnetic resonance imaging (MRI) inactive and active disease. Serum and CSF sHLA-G levels were more elevated in high than in low DEL/INS 14bp and +3142C>G sHLA-G producers and were different among the various combined HLA-G genotypes in both MRI inactive and active diseases. The highest and the lowest sHLA-G values were identified in MS patients with C/C,DEL/DEL and G/G,INS/INS genotypes, respectively. Our preliminary findings suggest that serum and CSF sHLA-G levels in MS could be influenced by HLA-G polymorphisms irrespective of the inflammatory microenvironment.