The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements

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The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements

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作者：Claudio Procaccini¹ ; ¹¹ ; Fortunata Carbone¹ ; ¹¹ ; Dario Di Silvestre² ; Francesca Brambilla² ; Veronica De Rosa¹ ; ³ ; Mario Galgani¹ ; Deriggio Faicchia⁴ ; Gianni Marone⁴ ; Donatella Tramontano⁵ ; Marco Corona⁶ ; Carlo Alviggi⁷ ; Antonio Porcellini⁸ ; Antonio La Cava⁹ ; Pierluigi Mauri² ; ¹⁰ ; Giuseppe Matarese¹ ; ⁵ ; ^{giuseppe.matarese@unina.it" class="auth_mail" title="E-mail the corresponding author}
关键词：Metabolism ; Regulatory T cells ; Conventional T cells ; Proteomic Analysis ; Immune Tolerance
刊名：Immunity
出版年：2016
出版时间：16 February 2016
年：2016
卷：44
期：2
页码：406-421
全文大小：6513 K

文摘

lass="label">•: Ex vivo human Treg cells are highly glycolytic and proliferating
lass="label">•: Ex vivo human Tconv cells use fatty-acid oxidation (FAO) and are non-proliferating
lass="label">•: In vitro proliferation of human Treg cells requires both glycolysis and FAO
lass="label">•: In vitro proliferation of human Tconv cells relies mainly on glycolysis

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