Neurophysiological assessment of neural network plasticity and connectivity: Progress towards early functional biomarkers for disease interception therapies in Alzheimer’s disease

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• 作者：C. Walsh ; W.H.I.M. Drinkenburg ; A. Ahnaou ; ^{aahnaou@its.jnj.com}
• 关键词：Aβ ; amyloid Beta ; ACh ; acetylcholine ; AChEI ; acetylcholinesterase inhibitor ; ACH ; amyloid cascade hypothesis ; AD ; Alzheimer&rsquo ; s disease ; APP ; amyloid precursor protein ; ARIA-E ; amyloid related imaging abnormalities related to edema ; CSF ; cerebrospinal fluid ; EEG ; electroencephalogram/electroencephalography ; EROS ; event-related oscillations ; ERP ; event-related potentials ; fAD ; familial Alzheimer&rsquo ; s disease ; fMRI ; functional MRI ; FTDP-17 ; frontotemporal dementia and parkinsonism linked to
• 刊名：Neuroscience & Biobehavioral Reviews
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：340-358
• 全文大小：1865 K
• 卷排序：73

文摘

Alzheimer’s disease (AD) is characterized by losses of synapses and connectivity between cortical and subcortical regions. Tau pathology is believed to be initiated much earlier in deeper brainstem networks before any sign of amyloid pathology or clinical cognitive symptoms. Various transgenic animal models have been developed, yet clinical failures have highlighted a clear disconnect in translational research. Longitudinal network connectivity analysis could provide early functional biomarkers for discovery of disease interception therapeutics.