Basophil mediated pro-allergic inflammation in vehicle-emitted particles exposure

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• 作者：Alexander M. Zakharenko^a ; ¹ ; Ayse Basak Engin^b ; ¹ ; Valery V. Chernyshev^a ; Vladimir V. Chaika^a ; Sergey M. Ugay^a ; Ramin Rezaee^c ; Gholamreza Karimi^d ; Vladimir A. Drozd^a ; Anna V. Nikitina^a ; Sergey F. Solomennik^a ; Olga R. Kudryavkina^a ; Liu Xin^e ; Yuan Wenpeng^e ; Manolis Tzatzarakis^f ; Aristidis M. Tsatsakis^a ; ^f ; ^{aris@med.uoc.gr} ; Kirill S. Golokhvast^a ; ^{droopy@mail.ru}
• 关键词：Vehicle emitted particles ; Basophil ; CD16+ cells ; CD4+ T cells ; Polycyclic aromatic hydrocarbons
• 刊名：Environmental Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：152
• 期：Complete
• 页码：308-314
• 全文大小：895 K
• 卷排序：152

文摘

Basophil sensitization is more important than cell count in VEP exposure. CD16+ cells are more effective than basophils on CD4+ T cell proliferation. CD16+ and CD16- monocytes respond to VEP exposure in opposite directions. CD8+ T cell proliferation is inhibited by all doses of VEPs. Globally, more stringent standards are needed for vehicle particle emissions.