New hydrosoluble perylene and coronene derivatives

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• 作者：Franceschin ; Marco ; Alvino ; Antonello ; Ortaggi ; Giancarlo ; Bianco ; Armandodoriano
• 关键词：Perylene ; Coronene ; Hydrosoluble ; G-quadruplex ; Telomerase inhibitors
• 刊名：Tetrahedron Letters
• 出版年：2004
• 出版时间：November 29, 2004
• 年：2004
• 卷：45
• 期：49
• 页码：9015-9020
• 全文大小：383 K

文摘

Several lipophilic perylene and coronene derivatives, employed mainly as liquid crystalline dyes are known and their synthesis has been widely studied. We have applied an analogue strategy using hydrophilic substituents to obtain highly water soluble perylene diimides (4) and a new hydrosoluble coronene derivative (CORON, 6), whose molecular features appear particularly suitable for inducing G-quadruplex DNA structures and inhibiting human telomerase.