Function/structure correlation in novel pH-dependent cationic liposomes for glioma cells transfection in vitro

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• 作者：Esposito ; Claudio ; Masotti ; Andrea ; Del Grosso ; Nicoletta ; Malizia ; Daniela ; Bianco ; Armandodoriano ; et. al.
• 关键词：gene therapy ; transfection ; glioma ; pH-dependent lipids ; cationic liposomes ; thé ; rapie gé ; nique ; transfection ; gliome ; lipides dé ; pendantes du pH ; liposomes cationiques
• 刊名：Comptes Rendus Chimie
• 出版年：2003
• 出版时间：May, 2003
• 年：2003
• 卷：6
• 期：5-6
• 页码：617-622
• 全文大小：168 K

文摘

Cationic liposomes are good candidates as gene carriers in cell biology due to their ability to bind DNA through electrostatic interactions. These liposomes are used as non-viral delivery systems in the gene therapy of glioma. pH-dependency and transfection efficiency of seven novel lipids (MORF-1, MORF-2, MORF-3, PIPR-1, PIPR-2, MM54 and DC-Amy) were studied. Two of these molecules (PIPR-2 and MM54) show at specific charge ratios better transfection efficiency than that of some commercially available liposomes. To cite this article: C. Esposito et al., C. R. Chimie 6 (2003).