Natural and synthetic G-quadruplex interactive berberine derivatives

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• 作者：Marco Franceschin ; Luigi Rossetti ; Anna D’ ; Ambrosio ; Stefano Schirripa ; Armandodoriano Bianco ; Giancarlo Ortaggi ; Maria Savino ; Christoph Schultes and Stephen Neidle
• 关键词：G-quadruplex ; Telomerase ; Alkaloid ; Berberine
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2006
• 出版时间：15 March 2006
• 年：2006
• 卷：16
• 期：6
• 页码：1707-1711
• 全文大小：316 K

文摘

The interaction of the natural alkaloid berberine with various G-quadruplex DNA structures and its ability to inhibit telomerase have been examined and compared with those of a synthetic piperidino derivative and the related compound coralyne. The results show that these molecules have selectivity for G-quadruplex compared to duplex DNA, and that their aromatic moieties play a dominant role in quadruplex binding.