Calcium signalling induced by in vitro exposure to silicium dioxide nanoparticles in rat pulmonary artery smooth muscle cells

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• 作者：Virginie Dubes^a ; ^b ; ^{cubitus2@hotmail.fr} ; Thibaud Parpaite^a ; ^b ; ^{cocal@hotmail.fr} ; Thomas Ducret^a ; ^b ; ^{thomas.ducret@u-bordeaux.fr} ; Jean-Fran&ccedil ; ois Quignard^a ; ^b ; ^{jean-francois.quignard@u-bordeaux.fr} ; Sté ; phane Mornet^a ; ^c ; ^{stephane.mornet@icmcb.cnrs.fr} ; Nora Reinhardt^a ; ^c ; ^{nora.reinhardt@icmcb.cnrs.fr} ; Isabelle Baudrimont^a ; ^b ; ^{isabelle.baudrimont@u-bordeaux.fr} ; Mathilde Dubois^a ; ^b ; ^{mathilde.dubois@u-bordeaux.fr} ; Vé ; ronique Freund-Michel^a ; ^b ; ^{veronique.michel@u-bordeaux.fr} ; Roger Marthan^a ; ^b ; ^d ; ^{roger.marthan@u-bordeaux.fr} ; Bernard Muller^a ; ^b ; ^{bernard.muller@u-bordeaux.fr} ; Jean-Pierre Savineau^a ; ^b ; ^{jean-pierre.savineau@u-bordeaux.fr} ; Arnaud Courtois^a ; ^b ; ^e ; ^{arnaud.courtois@u-bordeaux.fr}
• 关键词：PASMC ; pulmonary artery smooth muscle cells ; TRP ; transient receptor potential ; SAC ; stretch-activated channels
• 刊名：Toxicology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：375
• 期：Complete
• 页码：37-47
• 全文大小：1401 K
• 卷排序：375

文摘

SiO2 nanoparticles induced a Ca2+ signal in rat pulmonary artery smooth muscle cells. SiO2 nanoparticles induced the proliferation of rat pulmonary artery smooth muscle cells. This rise in Ca2+ was greater in arterial cells from rat suffering from pulmonary hypertension. This Ca2+ rise might occur, at least in part, through Transient Receptor potential channels.