Inhibition of aryl hydrocarbon receptor signaling and induction of NRF2-mediated antioxidant activity by cinnamaldehyde in human keratinocytes

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• 作者：Hiroshi Uchi ; MD ; PhD^a ; ^{uchihir@dermatol.med.kyushu-u.ac.jp} ; Mao Yasumatsu^b ; Saori Morino-Koga ; PhD^c ; Chikage Mitoma ; MD ; PhD^b ; Masutaka Furue ; MD ; PhD^a ; ^b
• 关键词：carboxyH2DCFDA ; 5-(and-6)-carboxy-2&prime ; 7ʹ-dichlorodihydrofluorescein diacetate ; AHR ; aryl hydrocarbon receptor ; ARNT ; AHR nuclear translocator ; BaP ; benzo[a]pyrene ; DRE ; dioxin responsive elements ; HO1 ; heme oxygenase-1 ; HRP ; horseradish peroxidase ; NRF2 ; nuclear factor erythroid 2-related factor 2 ; PAHs ; polycyclic aromatic hydrocarbons ; ROS ; reactive oxygen species
• 刊名：Journal of Dermatological Science
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：85
• 期：1
• 页码：36-43
• 全文大小：1191 K
• 卷排序：85

文摘

We explore phytochemicals that inhibit AHR activation in keratinocytes. Cinnamaldehyde contained in Cinnamomum cassia extract inhibits AHR activation. Cinnamaldehyde activates the NRF2/HO1 pathway and alleviates ROS production. The AHR and the NRF2/HO1 pathways are independently modulated by cinnamaldehyde. Formulae containing Cinnamomum cassia extract inhibits AHR activation.