Dichotomous effects of isomeric secondary amines containing an aromatic nitrile and nitro group on human aortic smooth muscle cells via inhibition of cystathionine-γ-lyase

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• 作者：Yajing Ji^a ; Austin Bowersock^b ; Alec R. Badour^b ; Neeraj Vij^c ; Stephen J. Juris^d ; David E. Ash^b ; Dillip K. Mohanty^b ; ^{Mohan1dk@cmich.edu}
• 关键词：Human aortic smooth muscle cell proliferation inducers and inhibitors ; l-homocysteine ; Isomeric secondary amines ; Cystathionine-γ-lyase
• 刊名：Biochimie
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：133
• 期：Complete
• 页码：103-111
• 全文大小：1385 K
• 卷排序：133

文摘

Two isomeric families (O and P) of N-alkyl-N-aryl amines are reported. The O family of amines induce and inhibit HASMC proliferation at low and at high concentrations respectively. The P family of amines inhibit HASMC proliferation at all concentrations. Amines belonging to the O family inhibit cystathionine-γ-lyase to a lower extent than the P family. The O and P families of amines increase intracellular homocysteine levels to varying extents.