Three-component reaction of triphenylphosphine, dialkyl but-2-ynedioate and arylidene pivaloylacetonitrile for diastereoselective synthesis of densely substituted 2,3-dihydrofurans

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• 作者：Wen-Jie Qi ; Ying Han ; ^{hanying@yzu.edu.cn} ; Chang-Zhou Liu ; Chao-Guo Yan ; ^{cgyan@yzu.edu.cn}
• 关键词：Multicomponent reaction ; Triphenylphosphine ; But-2-ynedioate ; Pivaloylacetonitrile ; 2 ; 3-Dihydrofuran
• 刊名：Chinese Chemical Letters
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：28
• 期：2
• 页码：442-445
• 全文大小：328 K
• 卷排序：28

文摘

The three-component reaction of triphenylphosphine, dialkyl but-2-ynedioate and arylidene pivaloylacetonitrile in dry methylene dichloride at room temperature resulted in unexpected densely substituted 1-(triphenyl-λ5-phosphanylidene)ethyl)-2,3-dihydrofurans in satisfactory yields with high diastereoselectivity. The relative configuration of the 2,3-dihydrofurans was elucidated by determination of single crystal structures.