Anxiety and risk assessment-related traits in a rat model of Spinocerebellar ataxia type 17

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• 作者：Elisavet I. Kyriakou^a ; ^b ; ^c ; ^{eky@noldus.nl} ; Giuseppe Manfré ; ^a ; ^b ; ^c ; Jesú ; s A. Spadaro^a ; Huu Phuc Nguyen^c ; ^d ; ^{Hoa.Nguyen@med.uni-tuebingen.de} ; Johanneke E.Van der Harst^a ; ^b ; Judith R. Homberg^a
• 关键词：Polyglutamine disease ; Model characterization ; Disease development ; C-Fos neuronal activation ; Elevated plus maze
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：321
• 期：Complete
• 页码：106-112
• 全文大小：667 K
• 卷排序：321

文摘

Anxiety as a common feature of several neurodegenerative/polyglutamine diseases is an important aspect for the face validity of an animal model for Spinocerebellar Ataxia type 17 (SCA17). Risk assessment and anxiety-like traits were characterised in 3–6–9 months old rats of a transgenic model for SCA17 using the standard behavioural test elevated plus maze. In addition, c-Fos immunostainings in the basolateral amygdala evaluated neuronal activation in correlation to the behavioural responses. The most prominent behavioural effect was a higher level of risk assessment in the transgenic rats. In addition, an increase in anxiety-related behaviour in these rats was found. Although the EPM caused no overall effect on c-Fos expression, a negative correlation with the anxiety-like behavioural response was observed. Our results suggest that the SCA17 rat model displays an anxious phenotype already at 3 months of age resembling the generalized anxiety in early symptomatic SCA17 patients, thus confirming the validity of this rat model.