文摘
Distinct patterns of HPA axis dysregulation in psychosis are observed for basal, stress-induced and awakening cortisol HPA axis alterations in clinical high risk populations resemble those observed in established psychosis, but are less consistent Confounding factors and challenges in the measurement of stress, cortisol, and symptomatic outcome affect interpretation of results Genetic, epigenetic, neurodevelopmental and environmental factors may modulate the effects of HPA axis abnormalities on psychosis progression HPA axis activity in psychosis appears to be associated with altered neurotransmitter activity, inflammatory processes and brain structure