Change in molecular weight due to important pfatp6 and pfmdr1 polymorphisms and susceptibility to antimalarial drug: Possible role of epigenetic phenomenon

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• 作者：Somsri Wiwanitkit¹ ; ^{somsriwiwan@hotmail.com} ; Viroj Wiwanitkit²
• 关键词：Polymorphism ; Malaria ; Drug ; Susceptibility ; Molecular weight
• 刊名：Asian Pacific Journal of Tropical Biomedicine
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：7
• 期：3
• 页码：181-182
• 全文大小：261 K
• 卷排序：7

文摘

Malaria is an important tropical mosquito borne infection. It is still the present global public health issue. The management of malaria requires antimalarial drugs. The resistance to antimalarial drugs is a very big problem. The genetic variant is proposed to be an important factor affecting susceptibility to antimalarial drug. Here, the authors studied the change in molecular weight due to important pfatp6 and pfmdr1 polymorphisms and further implied the interrelationship with susceptibility to antimalarial drug. The greatest change can be seen in case of G639D (of pfatp6 polymorphism) while the least change can be seen in the case of N1042D (of pfmdr1 polymorphism). The results from some studies imply that there must be other factors that affect the susceptibility to antimalarial drugs. Those factors might be protein conformation factors, epigenetic factors or environmental factors. Further studies on these aspects should be carried out. It is concluded for possible role of epigenetic phenomenon.