Development of a human live attenuated West Nile infectious DNA vaccine: Suitability of attenuating mutations found in SA14-14-2 for WN vaccine design

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Development of a human live attenuated West Nile infectious DNA vaccine: Suitability of attenuating mutations found in SA14-14-2 for WN vaccine design

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作者：Vladimir Yamshchikov ; ^{yaximik@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Marina Manuvakhova ; Efrain Rodriguez
关键词：WNV ; Vaccine ; iDNA ; JEV ; SA14-14-2 ; W956 ; W1806 ; Attenuation ; Envelope ; Mice
刊名：Virology
出版年：2016
出版时间：January 2016
年：2016
卷：487
期：Complete
页码：198-206
全文大小：1554 K

文摘

•: Further attenuation of a WN vaccine precursor is outlined.
•: Effect of SA14-14-2 attenuating mutations is tested.
•: Mechanism of attenuation is proposed and illustrated.
•: The need for additional attenuating mutations is justified.

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