Genetic stability of live attenuated vaccines against potentially pandemic influenza viruses

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Genetic stability of live attenuated vaccines against potentially pandemic influenza viruses

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作者：Irina Kiseleva^a ; ^{irina.v.kiseleva@mail.ru" class="auth_mail" title="E-mail the corresponding author} ; Irina Dubrovina^a ; Ekaterina Fedorova^a ; Natalie Larionova^a ; Irina Isakova&ndash ; Sivak^a ; Ekaterina Bazhenova^a ; Maria Pisareva^b ; Victoria Kuznetsova^a ; Jorge Flores^c ; Larisa Rudenko^a
关键词：Influenza ; Live attenuated influenza vaccine ; Pre-pandemic vaccine ; Genetic stability ; Vaccine virus shedding
刊名：Vaccine
出版年：2015
出版时间：8 December 2015
年：2015
卷：33
期：49
页码：7008-7014
全文大小：878 K

文摘

•: H5N2, H7N3, H2N2 potentially pandemic LAIV viruses were detected in vaccines.
•: We studied genetic stability of potentially pandemic LAIVs clinical isolates.
•: All LAIVs tested displayed high genetic stability of attenuating mutations.
•: No viral RNA was found in any of the placebo recipients after vaccination.

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