A practical synthesis of novel chiral sulfoxide-nitrogen ligands

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• 作者：Ming Wang^a ; Jianpeng Wei^a ; Qiaoling Fan^a ; Xuefeng Jiang^a ; ^b ; ^{xfjiang@chem.ecnu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Sulfoxide ; Chiral ligands ; Gram-scale preparation ; Oxidation
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：26 May 2016
• 年：2016
• 卷：72
• 期：21
• 页码：2671-2676
• 全文大小：674 K

文摘

Novel chiral sulfoxide-nitrogen ligands which are derived from amino alcohols were developed. All of fourteen sulfoxide-nitrogen ligands can be synthesized by three steps without any chiral auxiliary. In addition, every step of the synthesis can be achieved in gram-scale by using the preparation of L9–L12 as examples. These sulfoxide-nitrogen ligands may be applicable to the asymmetric catalytic 1,3-dipolar cycloaddition of azomethine ylide with alkylidene malonate.