Imidazolidinone based chiral auxiliary mediated acetate aldol reactions of isatin derivatives and stereoselective synthesis of 3-substituted-3-hydroxy-2-oxindoles

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• 作者：Mukesh Gangar ; Naresh Kashyap ; Kapil Kumar ; Sandeep Goyal ; Vipin A. Nair ; ^{vn74nr@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Chiral auxiliary ; Acetate aldol reaction ; Stereoselectivity ; Flustraminol ; Alline
• 刊名：Tetrahedron Letters
• 出版年：2015
• 出版时间：23 December 2015
• 年：2015
• 卷：56
• 期：51
• 页码：7074-7081
• 全文大小：3313 K

文摘

Acetate aldol reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one chiral auxiliary have been optimized with high yields and diastereoselectivity on various N-substituted isatins. The standardized reaction condition was employed for the stereoselective synthesis of furoindolines, and the pyrroloindole based natural products flustraminol B and N-benzyl alline.