Blood group antigens frequencies in the northeast of Iran

详细信息    查看全文

• 作者：Mohammad Reza Keramati^a ; Hossein Shakibaei^b ; Mohammad Ismail Kheiyyami^b ; Hossein Ayatollahi^a ; Zahra Badiei^c ; Maliheh Samavati^a ; Mohammad Hadi Sadeghian^a ;   ; ^{sadeghianmh@mums.ac.ir}
• 关键词：Blood groups ; Blood group systems ; Blood group antigens ; Blood group phenotypes
• 刊名：Transfusion and Apheresis Science
• 出版年：2011
• 出版时间：October 2011
• 年：2011
• 卷：45
• 期：2
• 页码：133-136
• 全文大小：160 K

文摘

Background

Identification of blood group antigen frequencies in a population has various benefits in transfusion medicine. Most data in the literature include frequencies of these antigens in European and American countries. In this study for the first time we have reported frequencies of these antigens in the northeast of Iran.

Materials and methods

Blood group antigens were characterized in the 522 blood donors in Mashhad, Iran. The following antigens including ABO, Rh (D, C, E, c, e), MNSs (M, N, S, s), Lutheran (Lu^a, Lu^b), P (P, P₁), Kell (K, k, Kp^a, Kp^b), Lewis (Le^a, Le^b), Duffy (Fy^a, Fy^b) and Kidd (Jk^a, Jk^b) were typed and phenotypes frequencies were expressed as a percentage.

Results

In the ABO blood group, the most common phenotype was O (33.9 % ) followed by A, B and AB. In the Rh blood group, the most common antigen was e (97.9 % ) and R₁r (31.8 % ) being the most common phenotype. The most common phenotypes for MNSs, P, Lu and Kell blood group were M+N+, S?s+, P₁, Lu (a?b+), K?k+ and Kp (a?b+). A very rare phenotype of Lu (a?b? was also observed in 2.7 % of cases. We found rare phenotypes of Le (a+b+) and Fy (a?b? in 7.9 % and 3.4 % of subjects, respectively.

Conclusion

We determined some differences in phenotype frequencies of blood group compared with other studies. We found higher frequencies of B blood group and also more frequencies of some rare phenotypes, Lu (a?b?, Le (a+b+) and Fy (a?b?.