Hybrid Methods Reveal Multiple Flexibly Linked DNA Polymerases within the Bacteriophage T7 Replisome

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• 作者：Jamie R. Wallen¹ ; ⁶ ; ^{jamiewallen@email.wcu.edu} ; Hao Zhang² ; Caroline Weis³ ; Weidong Cui² ; Brittni M. Foster¹ ; Chris M.W. Ho⁴ ; Michal Hammel³ ; John A. Tainer⁵ ; ³ ; Michael L. Gross² ; Tom Ellenberger⁴ ; ^{tome@biochem.wustl.edu}
• 关键词：DNA replication ; X-ray crystallography ; native mass spectrometry ; small-angle X-ray scattering
• 刊名：Structure
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：157-166
• 全文大小：3006 K
• 卷排序：25

文摘

Structure of the primase-helicase bound to three copies of DNA polymerase Hexamers and heptamers of primase-helicase bind multiple copies of DNA polymerase Presence of DNA alters the binding mode of DNA polymerase on the primase-helicase