Fiber optic biosensor for transdermal glucose based on the glucose binding protein

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• 作者：Cristina Tiangco^a ; ^dAuthor Vitae ; Dieudonne Fon^a ; ^b ; Neha Sardesai^a ; ^c ; Yordan Kostov^a ; ^c ; Fortunato Sevilla III^d ; Govind Rao^a ; ^b ; Leah Tolosa^a ; ^b ; ^{leah@umbc.edu}Author Vitae
• 关键词：Biosensor ; Optical fiber ; Transdermal glucose ; Glucose binding protein
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：242
• 期：Complete
• 页码：569-576
• 全文大小：1435 K
• 卷排序：242

文摘

This paper describes the development of a fiber optic glucose biosensing system for the detection of micromolar levels of transdermal glucose. The system is comprised of an optical fiber with microbeads of BADAN-labeled glucose binding protein at the tip. The optode is attached to a home-built mini-fluorimeter with the necessary optics and electronics. The system is controlled by a tablet PC. Detection of the spontaneous diffusion of μM glucose through an in vitro model skin system was demonstrated.