κ-Carrageenan: An effective drug carrier to deliver curcumin in cancer cells and to induce apoptosis

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• 作者：Malairaj Sathuvan^a ; ¹ ; Ramar Thangam^b ; ¹ ; Mani Gajendiran^c ; Raju Vivek^d ; Sengottuvelan Balasubramanian^c ; Subramani Nagaraj^a ; Palani Gunasekaran^e ; Balaraman Madhan^b ; ^{madhanclri@gmail.com} ; Ramasamy Rengasamy^a ; ^{profrrengasamy@yahoo.com}
• 关键词：κ-Carrageenan ; Curcumin ; Drug-carrier ; Cancer cells ; ROS generation ; Cellular apoptosis
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：160
• 期：Complete
• 页码：184-193
• 全文大小：3769 K
• 卷排序：160

文摘

κ-Car is a natural polymer which predominantly available in red seaweeds. κ-Car efficiently involved in release of curcumin at intracellular conditions. κ-Car-Cur effectively involved in cancer cell growth inhibition at lower concentrations of 40 μg/mL. κ-Car may act as a potential drug carrier for anti-cancer drug delivery applications.