Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

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Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

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作者：Tikvah K. Hayes¹ ; ² ; Nicole F. Neel² ; Chaoxin Hu³ ; Prson Gautam⁴ ; Melissa Chenard⁵ ; Brian Long⁵ ; Meraj Aziz⁶ ; Michelle Kassner⁶ ; Kirsten L. Bryant² ; Mariaelena Pierobon⁷ ; Raoud Marayati² ; Swapnil Kher² ; Samuel D. George² ; Mai Xu¹² ; ¹³ ; Andrea Wang-Gillam¹² ; ¹³ ; Ahmed A. Samatar⁵ ; ¹⁴ ; Anirban Maitra³ ; Krister Wennerberg⁴ ; Emanuel F. Petricoin III⁷ ; Hongwei H. Yin⁶ ; Barry Nelkin⁸ ; Adrienne D. Cox¹ ; ² ; ⁹ ; ¹⁰ ; Jen Jen Yeh¹ ; ² ; ⁹ ; ¹¹ ; Channing J. Der¹ ; ² ; ⁹ ; ^{cjder@med.unc.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Cancer Cell
出版年：2016
出版时间：11 January 2016
年：2016
卷：29
期：1
页码：75-89
全文大小：5376 K

文摘

•: Bimodal action: differential consequences of short-versus long-term ERK inhibition
•: ERK inhibitor sensitivity is associated with MYC degradation in vitro and in vivo
•: PI3K-AKT-mTOR signaling drives basal resistance to ERK inhibitor treatment
•: Resistance mechanisms are complex and display significant inter-tumor heterogeneity

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