Characterization and functional analysis of cellular immunity in mice with biotinidase deficiency

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Characterization and functional analysis of cellular immunity in mice with biotinidase deficiency

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作者：Kirit Pindolia^a ; ^b ; Hong Li^c ; ^d ; Cisley Cardwell^a ; Barry Wolf^a ; ^b ; ^{bwolf1@hfhs.org" class="auth_mail}
关键词：Biotinidase deficiency ; Biotinidase ; Biotin ; Cellular immunity ; Biotinidase-deficient mouse ; Multiple carboxylase deficiency
刊名：Molecular Genetics and Metabolism
出版年：May 2014
年：2014
卷：112
期：1
页码：49-56
全文大小：898 K

文摘

•: Lymphoid organs remain unaffected during Biotinidase deficiency.
•: Splenocyte repertoire of BTD mouse was normal except for increased CD4 counts.
•: BTD mouse had compromised lymphocyte proliferation response.
•: BTD mouse is a suitable model system for studying pathophysiology of the disorder.

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