High dietary menaquinone intake is associated with reduced coronary calcification

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• 作者：Joline W.J. Beulens ; Michiel L. Bots ; Femke Atsma ; Marie-Louise E.L. Bartelink ; Matthias Prokop ; Johanna M. Geleijnse ; Jacqueline C.M. Witteman ; Diederick E. Grobbee ; Yvonne T. van der Schouw
• 关键词：Vitamin K ; Menaquinone ; Phylloquinone ; Coronary calcification ; Cardiovascular disease
• 刊名：Atherosclerosis
• 出版年：2009
• 出版时间：April 2009
• 年：2009
• 卷：203
• 期：2
• 页码：489-493
• 全文大小：139 K

文摘

Background

Dietary vitamin K is thought to decrease risk of cardiovascular disease by reducing coronary calcification, but inconsistent results are reported. This may be due to different effects of vitamin K₁ (phylloquinone) and vitamin K₂ (menaquinone, MK), but few studies included both.

Methods

We investigated the association of intake of phylloquinone and menaquinone, including its subtypes (MK4–MK10), with coronary calcification in a cross-sectional study among 564 post-menopausal women. Phylloquinone and menaquinone intake was estimated using a food-frequency questionnaire.

Results

Sixty-two percent (n = 360) of the women had coronary calcification based on 1.5-mm thick slices. Phylloquinone intake was not associated with coronary calcification with a relative risk (RR) of 1.17 (95 % -confidence interval: 0.96–1.42; p_trend = 0.11) of the highest versus lowest quartile. Menaquinone intake was associated with decreased coronary calcification with an RR of 0.80 (95 % -CI: 0.65–0.98; p_trend = 0.03).

Conclusion

This study shows that high dietary menaquinone intake, but probably not phylloquinone, is associated with reduced coronary calcification. Adequate menaquinone intakes could therefore be important to prevent cardiovascular disease.