The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats

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The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats

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作者：Nadia Khan^a ; Ali Saad^a ; Syed M. Nurulain^a ; Fouad H. Darras^b ; Michael Decker^b ; ^c ; Bassem Sadek^a ; ^{bassem.sadek@uaeu.ac.ae" class="auth_mail" title="E-mail the corresponding author}
关键词：Histamine H3 receptor ; Acetylcholinesterase ; Dual-acting ligand ; Learning ; Memory ; Inhibitory avoidance test ; Pyrilamine ; Zolantidine.
刊名：Behavioural Brain Research
出版年：2016
出版时间：15 January 2016
年：2016
卷：297
期：Complete
页码：155-164
全文大小：2292 K

文摘

•: The effects of UW-MD-71, a highly selective and dual-acting H3R antagonist and AChEI, on acquisition, consolidation, retrieval, and dizocilpine-induced amnesia were tested.
•: Acute UW-MD-71 administration improved retrieval dose-dependently and ameliorated dizocilpine-induced amnesia.
•: The results are the first demonstration for in vivo effectiveness of such a dual-acting ligand and shed light on their mode of action in mediating procognitive effects.