Synthetic approach and functionalization of novel 4-anilinoquinolino-quinazoline heterocyclic scaffolds

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• 作者：Chamseddine Derabli^a ; Raouf Boulcina^a ; ^b ; ^{r.boulcina@univ-batna2.dz} ; Gilbert Kirsch^c ; Abdelmadjid Debache^a
• 关键词：Quinazoline derivatives ; 4-Anilinoquinazolines ; Quinolino-quinazoline hybrids ; SNAr reaction
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：26 January 2017
• 年：2017
• 卷：73
• 期：4
• 页码：351-358
• 全文大小：684 K
• 卷排序：73

文摘

An efficient and high yielding protocol is reported for the synthesis of new class of 4-anilinoquinolino-quinazoline hybrids. The target compounds were prepared first by the reaction of 2-aminobenzamide with 2-chloroquinoline-3-carbaldehydes. After oxidation and chlorination, the key 2-quinolyl-4-chloroquinazolines were converted to the corresponding 2-(2-arylaminoquinolyl)-4-arylaminoquinazolines and N-heteroaryl-2-(2-(heteroarylamino)quinolin-3-yl)quinazolin-4-amines.