NeuCode Proteomics Reveals Bap1 Regulation of Metabolism

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NeuCode Proteomics Reveals Bap1 Regulation of Metabolism

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作者：Joshua M. Baughman¹ ; ¹⁴ ; Christopher M. Rose¹⁰ ; ¹⁴ ; Ganesh Kolumam² ; ¹⁴ ; Joshua D. Webster³ ; Emily M. Wilkerson¹⁰ ; Anna E. Merrill¹⁰ ; Timothy W. Rhoads¹³ ; Rajkumar Noubade⁴ ; Paula Katavolos⁵ ; Justin Lesch⁶ ; Donald S. Stapleton¹¹ ; Mary E. Rabaglia¹¹ ; Kathy L. Schueler¹¹ ; Raymond Asuncion⁷ ; Melanie Domeyer⁷ ; Jose Zavala-Solorio² ; Michael Reich⁸ ; Jason DeVoss⁶ ; Mark P. Keller¹¹ ; Alan D. Attie¹¹ ; Alexander S. Hebert¹³ ; Michael S. Westphall¹³ ; Joshua J. Coon¹⁰ ; ¹² ; ¹³ ; ¹⁵ ; ^{jcoon@chem.wisc.edu" class="auth_mail" title="E-mail the corresponding author} ; Donald S. Kirkpatrick¹ ; ¹⁵ ; ^{kirkpatrick.donald@gene.com" class="auth_mail" title="E-mail the corresponding author} ; Anwesha Dey⁹ ; ¹⁵ ; ^{dey.anwesha@gene.com" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：12 July 2016
年：2016
卷：16
期：2
页码：583-595
全文大小：5055 K

文摘

•: NeuCode is an accurate quantitative proteomics method of reducing in vivo labeling time
•: Bap1 deletion perturbs multiple metabolic pathways in pancreas and liver
•: Histones and mitochondrial membrane proteins are hyperubiquitinated in Bap1ko livers
•: Liver-specific Bap1ko mice are perinatal lethal with metabolic defects

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