Conserved Fever Pathways across Vertebrates: A Herpesvirus Expressed Decoy TNF-α Receptor Delays Behavioral Fever in Fish

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• 作者：Krzysztof Rakus¹ ; ² ; ¹¹ ; Maygane Ronsmans¹ ; ¹¹ ; Maria Forlenza³ ; Maxime Boutier¹ ; M. Carla Piazzon³ ; Joanna Jazowiecka-Rakus¹ ; ⁴ ; Derek Gatherer⁵ ; Alekos Athanasiadis⁶ ; Fré ; dé ; ric Farnir⁷ ; Andrew J. Davison⁸ ; Pierre Boudinot⁹ ; Thomas Michiels¹⁰ ; Geert F. Wiegertjes³ ; Alain Vanderplasschen¹ ; ¹² ; ^{a.vdplasschen@ulg.ac.be}
• 关键词：behavioral fever ; fever ; herpesvirus ; cyprinid herpesvirus 3 ; host-virus interactions ; pathogen-host-environment interplay ; immune evasion mechanisms ; innate immunity ; tumor necrosis factor α ; viral decoy receptor for cytokine
• 刊名：Cell Host & Microbe
• 出版年：2017
• 出版时间：8 February 2017
• 年：2017
• 卷：21
• 期：2
• 页码：244-253
• 全文大小：3502 K
• 卷排序：21

文摘

Behavioral fever exhibited by carp in response to CyHV-3 infection is host beneficial CyHV-3 ORF12 delays behavioral fever expression, thereby promoting its own replication CyHV-3 ORF12 encodes a soluble decoy receptor for TNF-α TNF-α is a mediator of behavioral fever expressed by CyHV-3 infected carp