Exacerbation of experimental autoimmune encephalomyelitis by passive transfer of IgG antibodies from a multiple sclerosis patient responsive to immunoadsorption

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• 作者：Rosetta Pedotti ; Silvia Musio ; Stefano Scabeni ; Cinthia Farina ; Pietro Luigi Poliani ; Emanuela Colombo ; Massimo Costanza ; Angela Berzi ; Fabrizio Castellucci ; Emilio Ciusani ; Paolo Confalonieri ; Bernhard Hemmer ; Renato Mantegazza ; Carlo Antozzi
• 关键词：EAE ; experimental autoimmune encephalomyelitis ; LNCs ; lymph node cells ; MS ; multiple sclerosis ; PBS ; phosphate buffer saline ; PLP ; myelin proteolipid protein ; Th ; T helper ; TPE ; plasma exchange
• 刊名：Journal of Neuroimmunology
• 出版年：2013
• 出版时间：15 September, 2013
• 年：2013
• 卷：262
• 期：1-2
• 页码：19-26
• 全文大小：1644 K

文摘

The pathogenic role of antibodies in multiple sclerosis (MS) is still controversial. We transferred to mice with experimental autoimmune encephalomyelitis (EAE), animal model of MS, IgG antibodies purified from a MS patient presenting a dramatic clinical improvement during relapse after selective IgG removal with immunoadsorption. Passive transfer of patient's IgG exacerbated motor paralysis and increased mouse central nervous system (CNS) inflammation and demyelination. Binding of patient's IgG was demonstrated in mouse CNS, with a diffuse staining of white matter oligodendrocytes. These data support a growing body of evidence that antibodies can play an important role in the pathobiology of MS.