C-terminally truncated constitutively active androgen receptor variants and their biologic and clinical significance in castration-resistant prostate cancer

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• 作者：Anca Azoitei^a ; Axel S. Merseburger^b ; Beate Godau^b ; M. Raschid Hoda^b ; Evi Schmid^c ; Marcus V. Cronauer^b ; ^{marcus.cronauer@uksh.de}
• 关键词：aa ; amino-acids ; ADT ; androgen deprivation therapy ; AR ; androgen receptor ; ARΔLBD ; androgen receptor lacking a functional ligand binding domain ; AR-V ; AR splice variant ; BET ; bromodomain and extra-terminal ; CE ; cryptic exon ; CRPC ; castration-resistant prostate cancer ; CTC ; circulating tumor cell ; CTD ; carboxy-terminal domain ; DBD ; DNA-binding domain ; EMT ; epithelial-mesenchymal transition ; FFPE ; formalin-fixed paraffin-embedded ; HR ; hinge region ; I ; intron ; IF ; immunofluorescence ; IGF-1 ; insulin
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：38-44
• 全文大小：718 K
• 卷排序：166

文摘

ARΔLBDs are products of alternative splicing (AR-V), premature stop codons (Q641X) or enzymatic cleavage (tr-AR). ARΔLBDs can be subdivided into two structurally and functionally distinct subgroups, depending on the presence/absence of a hinge region. Various ARΔLBDs are involved in PCa progression (castration resistance, EMT, glutaminolysis etc). ARΔLBDs like AR-V7 are highly interesting new prognostic and therapeutic targets.