ERAD deficiency blocks the transition from large pre-B cells to small pre-B cells
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ERAD manages a B cell developmental checkpoint by attenuating pre-BCR signaling
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The pre-BCR complex is an endogenous Sel1L-Hrd1 ERAD substrate in B cells
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Pre-BCR degradation by the Sel1L-Hrd1 complex requires the ER chaperone BiP
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