Study of circulating IgG antibodies to peptide antigens derived from BIRC5 and MYC in cervical cancer

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Study of circulating IgG antibodies to peptide antigens derived from BIRC5 and MYC in cervical cancer

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作者：Yangchun Xu^a ; ¹ ; Yonglong Jin^a ; ¹ ; Linlin Liu^a ; Xuan Zhang^a ; ^{zhangxuankj@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yubing Chen^a ; ^{ybchend@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jun Wei^b
关键词：AUC ; area under ROC curve ; BIRC5 ; baculoviral IAP repeat-containing protein 5 isoform 2 ; HPV ; human papillomavirus ; IgG ; immunoglobulin G ; MYC ; myc proto-oncogene protein ; ROC ; receiver operating characteristic curve ; SBI ; specific binding index ; SCC ; squamous cell carcinoma ; TAAs ; tumor-associated antigens
刊名：FEBS Open Bio
出版年：2015
出版时间：2015
年：2015
卷：5
期：Complete
页码：198-201
全文大小：408 K

文摘

•: Autoantibodies to BIRC5 and MYC were measured in cervical cancer patients and a control group.
•: There was a significant difference in circulating levels of these autoantibodies in the patient and control groups.
•: ROC analysis suggests that anti-BIRC5 IgG has a higher sensitivity than anti-MYC IgG.
•: Anti-BIRC5 IgG could serve as a biomarker for the early diagnosis of cervical cancer.

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