Injured hepatocyte-released microvesicles induce bone marrow-derived mononuclear cells differentiation

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Injured hepatocyte-released microvesicles induce bone marrow-derived mononuclear cells differentiation

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作者：Laura Simon^a ; ^b ; Mó ; nica Ló ; pez^a ; ^b ; Carolina Uribe-Cruz^a ; Davi Fernandes Peralvo Vergara^a ; Lucia Silla^c ; Ursula Matte^a ; ^b ; ^d ; ^{umatte@hcpa.ufrgs.br" class="auth_mail" title="E-mail the corresponding author}
关键词：BMMCs ; Bone marrow-derived mononuclear cells ; CCl4 ; Carbon tetrachloride ; NAD ; Non-adherent ; MVs ; Microvesicles ; MSCs ; Mesenchymal stem cells ; ED1+ ; Monocyte/macrophage marker ; MACS ; Magnetic-activated cell sorting ; DMEM ; Dulbecco's modified eagle medium ; FBS ; Fetal bovine serum ; P/S ; Penicillin/streptomycin ; CO2 ; Carbon dioxide ; FITC ; Fluorescein isothiocyanate ; PE ; Phycoerythrin ; CD29 ; Integrin β1 ; CD90 ; Thy-1 ; CD45 ; lymphocyte common antigen ; CD31 ; Platelet endothelial cell adhesion molecule
刊名：Differentiation
出版年：2015
出版时间：July-October 2015
年：2015
卷：90
期：1-3
页码：40-47
全文大小：2618 K

文摘

•: Differentiation of NAD BMMC into hepatocyte-like cells, other than MSC and monocytes.
•: Expression of hepatocyte genes and proteins occurred after 24 h of co-culture.
•: Only co-culture with injured cells promoted NAD BMMCs differentiation.
•: Isolated MVs from co-culture with injured hepatocytes carried liver-specific mRNAs.
•: The uptake of MVs from NAD cells was confirmed in Albumin and PKH26-positive cells.

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