Transplantation of bone marrow mononuclear cells prolongs survival, delays disease onset and progression and mitigates neuronal loss in pre-symptomatic, but not symptomatic ALS mice

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Transplantation of bone marrow mononuclear cells prolongs survival, delays disease onset and progression and mitigates neuronal loss in pre-symptomatic, but not symptomatic ALS mice

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作者：Gianina Teribele Venturin^a ; ^b ; Samuel Greggio^a ; ^b ; Gabriele Zanirati^b ; Daniel Rodrigo Marinowic^c ; Iuri Marques de Oliveira^d ; Joã ; o Antonio Pê ; gas Henriques^d ; Jaderson Costa DaCosta ; M.D. ; Ph.D^a ; ^b ; ^{jcc@pucrs.br" class="auth_mail" title="E-mail the corresponding author}
关键词：ALS ; amyotrophic lateral sclerosis ; BMMCs ; bone marrow mononuclear cells ; ChAT ; choline acetyltransferase ; EGFP ; enhanced green fluorescent protein ; EGFPBMMC-70 ; SOD1G93A mice transplanted at 70 ; days with BMMCs from C57BL/6-EGFP mice ; EGFPBMMC-110 ; SOD1G93A mice transplanted at 110 ; days with BMMCSs from C57BL/6-EGFP mice ; GLT1 ; glutamate transporter 1 ; MSC ; mesenchymal stem cells ; mSOD1BMMC-70 ; SOD1G93A mice transplanted at 70 ; days with BMMCs from SOD1G93A mice ; mSOD1BMMC-110 ; SOD
刊名：Neuroscience Letters
出版年：2016
出版时间：28 October 2016
年：2016
卷：633
期：Complete
页码：182-188
全文大小：1540 K

文摘

•: We investigate the effect of bone marrow mononuclear cells (BMMC) in ALS mice.
•: Pre-symptomatic BMMC transplantation improves the animal’s clinical condition.
•: Only non-mSOD1 BMMC are beneficial in late symptomatic animals.
•: Early administration of BMMC promotes better outcomes.