The effects of D3R on TLR4 signaling involved in the regulation of METH-mediated mast cells activation

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The effects of D3R on TLR4 signaling involved in the regulation of METH-mediated mast cells activation

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作者：Li Xue^a ; ^b ; ¹ ; Yan Geng^b ; ¹ ; Ming Li^c ; Yao-Feng Jin^d ; Hui-Xun Ren^a ; Xia Li^e ; Feng Wu^f ; Biao Wang^a ; Wei-Ying Cheng^a ; Teng Chen^g ; Yan-Jiong Chen^a ; ^{chenyanjiong@126.com" class="auth_mail" title="E-mail the corresponding author}
关键词：METH ; methamphetamine ; HIV ; human immunodeficiency virus ; D3R ; dopamine D3 receptor ; DA ; dopamine ; LPS ; lipopolysaccharide ; MCs ; mast cells ; TNF-α ; tumor necrosis factor ; TLR ; Toll-like receptor ; NS ; normal saline ; BMMCs ; bone marrow-derived mast cells ; SCF ; stem cell factor ; ELISA ; Enzyme-linked Immunosorbent Assay
刊名：International Immunopharmacology
出版年：2016
出版时间：July 2016
年：2016
卷：36
期：Complete
页码：187-198
全文大小：1974 K

文摘

•: METH suppresses LPS-induced MC activation in mouse intestines.
•: METH suppresses LPS-induced cytokines production in mouse BMMCs.
•: D3R regulates the effect of METH on LPS-induced MCs activation.
•: METH modulates LPS-induced TLR4, MAPK and NF-κB signaling via D3R in mouse BMMCs.

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