Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

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• 作者：Bo YU^a ; ^{yuboshi@263.com" rel="nofollow} ; HongYing WU^b ; Fang LI^c ; Jie GONG^c ; DunJin ZHOU^c ; ZhiFeng ZHANG^c ; XiaoGuang YANG^a ; ZhenWu HUANG^a ; ^{zhenwuhuang@sina.com" rel="nofollow} [Author vitae]
• 关键词：FokI VDR genotype ; Calcium supplementation ; Bone mineral accretion after weaning ; Chinese women ; Low dietary calcium intake
• 刊名：Biomedical and Environmental Sciences
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：24
• 期：3
• 页码：243-248
• 全文大小：288 K

文摘

Objective

To investigate the effect of calcium supplementation on bone mineral density (BMD) in Chinese women with different FokI vitamin D receptor (VDR) genotypes (FF, Ff, and ff) after weaning or resumption of menstruation during lactation.

Methods

A total of 40 subjects with the same FokI VDR genotype were randomly divided into two groups: one received calcium tablet (600 mg once daily as CaCO₃) and the other placebo tablet once daily for 1 year. At baseline, BMD was measured by dual-energy X-ray absorptiometry at lumbar spine (L2-L4) and at left hip whereas serum PICP, serum OC, and urinary CTX, serum 25(OH)VitD₃, and serum estradiol were measured at weaning and 1 year thereafter.

Results

After the intervention, BMD at lumbar spine and at left hip increased significantly in all these women with a trend among different FokI VDR genotypes such as FF > Ff > ff (P<0.05, <0.01, and <0.001, respectively). BMD at lumbar spine in women with FF VDR genotype increased much more rapidly than in those with ff VDR genotype (P<0.05). Compared with the control group women with the FF genotype regained more BMD after calcium supplementation (P<0.05).

Conclusion

Daily calcium 600 mg supplementation has beneficial effect on the bone health of women with FF VDR genotype.