Molecular characterization of a bactericidal permeability-increasing protein/lipopolysaccharide-binding protein from black rockfish (Sebastes schlegelii): Deciphering its putative antibacterial role

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• 作者：Seongdo Lee^a ; ^b ; ¹ ; Don Anushka Sandaruwan Elvitigala^a ; ^b ; ^c ; ¹ ; Sukkyoung Lee^a ; ^b ; Hyun Chul Kim^d ; Hae-Chul Park^e ; ^{hcpark67@korea.ac.kr} ; Jehee Lee^a ; ^b ; ^{jehee@jejunu.ac.kr}
• 关键词：LBP/BPI ; Black rockfish ; Antibacterial activity ; Immune stimulation ; Transcriptional regulation
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：67
• 期：Complete
• 页码：266-275
• 全文大小：3130 K
• 卷排序：67

文摘

Homolog of BPI/LBP was identified from black rockfish (RfBPI/LBP). Rf RfBPI/LBP resembled typical domain architecture of its homologues. Recombinant RfBPI/LBP showed selective antibacterial and LPS binding activity. RfBPI/LBP was ubiquitously expressed in tissues under physiological conditions. Transcriptional level of RfBPI/LBP was modulated under pathogenic stress.