Combined effects of antiorthostatic suspension and ionizing radiation on the behaviour and neurotransmitters changes in different brain structures of rats

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• 作者：V.S. Kokhan^a ; ^{viktor_kohan@hotmail.com} ; M.I. Matveeva^a ; A.S. Bazyan^b ; V.S. Kudrin^c ; A. Mukhametov^d ; A.S. Shtemberg^a
• 关键词：CNS risks ; Antiorthostatic suspension ; Ionizing radiation ; Cognition ; Neurotransmitters changes
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：320
• 期：Complete
• 页码：473-483
• 全文大小：1002 K
• 卷排序：320

文摘

The study of influence of microgravity (model antiorthostatic suspension) and the combined irradiation (gamma-rays and protons in Bragg peak) revealed significant apologies psycho-emotional status and cognitive abilities of experimental animals—rats. Changes in the content of monoamines and their metabolites, and acetylcholine were detected in the hippocampus, hypothalamus and prefrontal cortex in response to the model of microgravity and ionizing radiation alone, but not in combination. We retrieved the first evidences that microgravity model’s and ionizing radiation can act antagonistically regarding the psycho-emotional status and the cognitive abilities, which is also associated with a reduction of alterations in the monoamines content in the studied brain structures.