A Rapid Induction Mechanism for Lin28a in Trophic Responses

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• 作者：Alexandra M. Amen¹ ; Claudia R. Ruiz-Garzon¹ ; Jay Shi² ; Megha Subramanian¹ ; Daniel L. Pham¹ ; Mollie K. Meffert¹ ; ² ; ³ ; ^mkm@jhmi.edu
• 关键词：Lin28 ; microRNA biogenesis ; Let-7 microRNA ; TRBP ; Dicer ; BDNF ; synaptic plasticity ; dendritic spine ; trophic response ; MAPK
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：65
• 期：3
• 页码：490-503.e7
• 全文大小：3529 K
• 卷排序：65

文摘

BDNF rapidly stabilizes Lin28a, but not Lin28b, by MAPK-dependent TRBP phosphorylation Lin28a, but not Lin28b, associates with TRBP in the miRNA-generating complex Phospho-TRBP requires Lin28a to mimic neurotrophin-induced dendritic spine growth MAPK-dependent Lin28a induction by trophic cues is conserved in diverse primary cells